Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.

Pain (Neuropathies, in general)

Key Findings

We conclude that the contribution of CB1-type receptors expressed on the peripheral terminals of nociceptors to cannabinoid-induced analgesia is paramount, which should enable the development of peripherally acting CB1 analgesic agonists without any central side effects.

Information and Links


Link: Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.

Year: 2007

DOI: 10.1038/nn1916


Ratings

(How Ratings Work)

Pain (Neuropathies, in general) — 2


Possible to probable range of efficacy of cannabis for treatment of Pain (Neuropathies, in general) according to the results found in this study.

Drugs Used

Cannabinoid receptor CB1 studied